Synthesis of citrovorum factor in rats given chloretone.

Ascorbic Acid Synthesis from D-Glucose-%C1* in the Liver of the Intact Rat

Evidence that glucose1 is the ultimate g-carbon precursor of ascorbic acid in the rat was first obtained by Jackel, Mosbach, Burns, and King (1). They administered uniformly labeled glucose-C** to Chloretone-treated rats and recovered uniformly labeled ascorbic acid from the urine. Subsequently, Horowitz, Doerschuk, and King (2) and Burns and Mosbach (3) discovered that when glucose-l-C14 was a...

Further observations on the biosynthesis of L-ascorbic acid from D-glucose in the rat.

Previous studies showed that the intact carbon chain of glucose can serve as a precursor for the synthesis of ascorbic acid in the rat (l-3). Evidence for such a precursor relationship came from experiments in which glucose tracers labeled in carbon 1 and carbon 6 were administered to rats, and the L-ascorbic acid isolated from urine was labeled predominantly in carbon 6 and carbon 1, respectiv...

Synthesis of citrovorum factor by Leuconostoc citrovorum; potentiation by ascorbic acid.

Ascorbic acid synthesis from D-glucose-2-C14 in the liver of the intact rat.

Evidence that glucose1 is the ultimate g-carbon precursor of ascorbic acid in the rat was first obtained by Jackel, Mosbach, Burns, and King (1). They administered uniformly labeled glucose-C** to Chloretone-treated rats and recovered uniformly labeled ascorbic acid from the urine. Subsequently, Horowitz, Doerschuk, and King (2) and Burns and Mosbach (3) discovered that when glucose-l-C14 was a...

Effects of a folic acid antagonist on nucleic acid metabolism.

Microbiological evidence (1) first implicated folic acid in nucleic acid synthesis, and several lines of investigation suggest that citrovorum factor, or another derivative of folic acid, may function in some manner as a coenzyme in the metabolism of a l-carbon moiety. The function of the formy1 group in rhizopterin (2) and citrovorum factor (3) has not been clarified. The incorporation of form...